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Breaking New Ground: TMS, IV Ketamine, and Spravato in Enhancing Neuroplasticity

In recognition of Brain Awareness Week, it’s imperative to shine a light on some of the most innovative treatments that are reshaping our approach to mental health care. Traditional therapies and medications have long been the cornerstone of treating conditions like depression, anxiety, and other mood disorders. However, they don’t always work for everyone, and the quest for more effective treatments has led to groundbreaking innovations. Among these, Transcranial Magnetic Stimulation (TMS), Intravenous (IV) Ketamine, and SPRAVATO® (esketamine) are leading the charge, not just in treating symptoms but in fundamentally altering the brain’s neuroplasticity to foster long-term health and well-being. 

TMS: A Magnetic Approach to Mental Health 

Transcranial Magnetic Stimulation (TMS) is a non-invasive procedure that uses magnetic fields to stimulate nerve cells in the brain. It’s primarily used to treat depression and anxiety, especially in cases where other treatments have not been effective. TMS works by targeting specific areas of the brain associated with mood regulation. 

The Impact on Neuroplasticity

Research suggests that TMS can induce changes in neuronal activity, promoting neuroplasticity. Neuroplasticity refers to the brain’s ability to reorganize itself by forming new neural connections throughout life. This ability is crucial for learning, memory, and recovery from brain injury. By enhancing neuroplasticity, TMS can help the brain ‘rewire’ itself, potentially leading to long-term improvements in mental health conditions. 

IV Ketamine: A New Hope for Rapid Relief

Ketamine, once known primarily for its use as an anesthetic and its illicit use, has emerged as a promising treatment for severe depression, including treatment-resistant depression. Administered intravenously under clinical supervision, IV Ketamine has been shown to produce rapid antidepressant effects, sometimes within hours of treatment.

The Role in Neuroplasticity 

Ketamine’s impact on neuroplasticity is a key part of its effectiveness. It is thought to stimulate the growth of new synapses in the brain, essentially creating new pathways for thoughts and emotions that circumvent the dysfunctional patterns associated with depression. This can lead to lasting changes in the brain, offering hope for durable relief from symptoms. 

SPRAVATO®: The Nasal Spray Changing Lives 

Spravato, the nasal spray form of esketamine (a chemical cousin of ketamine), was approved by the FDA in 2019 for treatment-resistant depression, in conjunction with an oral antidepressant. Like IV Ketamine, Spravato targets NMDA receptors in the brain but is administered in a much more user-friendly way, making it an accessible option for many patients.

Spravato and Neuroplasticity 

Esketamine’s effects on neuroplasticity are similar to those of ketamine, promoting the rapid formation of new neural connections. Its approval marked a significant milestone in the treatment of depression, offering a new lifeline for those who have not found relief through other treatments. 


1200 628 Taylor Carter

Taylor Carter

Taylor Carter is a dynamic Senior Marketing Manager with a passion for crafting compelling narratives and driving impactful campaigns. She has been an integral part of the Hopemark Health team for the past two years. By combining industry insights and medical facts with a deep understanding of the patient experience, Taylor continuously seeks to uplift and empower individuals on their journey to well-being.

Article by: Taylor Carter